Logan B K
Washington State Toxicology Laboratory, Forensic Laboratory Services Bureau, Seattle 98134, USA.
J Anal Toxicol. 2001 Jul-Aug;25(5):400-4. doi: 10.1093/jat/25.5.400.
Methamphetamine is currently enjoying a resurgence of popularity as a recreational drug. It presents a number of challenges to the forensic toxicologist both analytically and interpretively, and these latter interpretive issues are considered here. This review also discusses the current popular syntheses which account for the widespread domestic synthesis of the drug; the demographics of methamphetamine use in the United States as assessed from the Drug Abuse Warning Network (DAWN) data; developments in research of the neurotransporter pharmacology of the drug and its implications for interpretive forensic toxicology; the psychomotor effects of the drug and its potential for cognitive and functional impairment; interpretive issues related to postmortem blood drug concentrations and how these are impacted by evidence for incomplete distribution and the potential for postmortem redistribution; and, finally, concerns caused by designer methamphetamine analogues. All data indicate that methamphetamine and its analogues will present significant interpretive challenges to forensic toxicologists as the popularity of the drug continues to grow.
甲基苯丙胺作为一种消遣性毒品，目前正再度流行起来。它在分析和解释方面给法医毒物学家带来了诸多挑战，本文将探讨后者这些解释性问题。本综述还讨论了导致该药物在国内广泛合成的当前流行合成方法；根据药物滥用警示网络（DAWN）数据评估的美国甲基苯丙胺使用人群特征；该药物神经递质药理学研究进展及其对法医毒物学解释的影响；该药物的精神运动效应及其导致认知和功能损害的可能性；与死后血液药物浓度相关的解释性问题以及这些问题如何受到分布不完全证据和死后再分布可能性的影响；最后，还讨论了设计甲基苯丙胺类似物引发的问题。所有数据表明，随着该药物的流行持续增长，甲基苯丙胺及其类似物将给法医毒物学家带来重大的解释性挑战。
