抗人白细胞抗原抗血清对巨噬细胞与T细胞相互作用的影响。
Effect of anti-HLA antisera on macrophage-T-cell interactions.
作者信息
Geha R S, Milgrom H, Broff M, Alpert S, Martin S, Yunis E J
出版信息
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4038-41. doi: 10.1073/pnas.76.8.4038.
Abstract
Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement. Macrophages pulsed for 18 hr with antigen and then washed were capable of triggering T-cell proliferation. Addition of anti-DRw but not anti-HLA (A and B loci) antisera during the pulse period inhibited the macrophages' ability to trigger T-cell proliferation. The data obtained indicate that human T cells recognize and proliferate in response to antigen presented by the macrophages in association with Ia-like antigens.
摘要
已证明，人T淋巴细胞仅在巨噬细胞存在的情况下才会对破伤风类毒素抗原产生增殖反应。添加到培养物中的抗DRw抗血清可抑制这种反应，但抗HLA（A和B位点）抗血清则不能抑制；用抗DRw抗血清和补体预处理巨噬细胞而非T细胞也可抑制这种反应。用抗原脉冲处理18小时后再洗涤的巨噬细胞能够触发T细胞增殖。在脉冲期添加抗DRw抗血清而非抗HLA（A和B位点）抗血清会抑制巨噬细胞触发T细胞增殖的能力。所获得的数据表明，人T细胞识别与Ia样抗原相关联的巨噬细胞呈递的抗原并对其产生增殖反应。
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