Latrache H, Bourlioux P, Karroua M, Zahir H, Hakkou A
Laboratoire de Microbiologie, Faculté de Pharmacie, Université Paris XI, 92 296 Chátenay-Malabry, France.
Folia Microbiol (Praha). 2000;45(6):485-90. doi: 10.1007/BF02818714.
Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenic Escherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+. The effect of NIQ on the cell surface was not related to the bacteriostatic effect of this agent. The increase in nitrogen and decrease in phosphate content in the cell surface was found in the presence of NIQ. NIQ did not inhibit the expression of fimbriae.
亚抑制浓度（亚最小抑菌浓度）的硝咯喹啉（5-硝基-8-喹啉醇；NIQ）降低了尿路致病性大肠杆菌对导管表面的黏附，并显著增强了细胞表面疏水性。在亚最小抑菌浓度的NIQ存在时以及在过量Mg2+存在时，表面疏水性均增加。NIQ对细胞表面的作用与该药物的抑菌作用无关。在NIQ存在时，发现细胞表面氮含量增加而磷含量减少。NIQ不抑制菌毛的表达。
