Gasiorowski J, Szybejko-Machaj G, Machaj A
Katedra i Klinika Chorób Zakaźnych Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 2001 Jun;10(60):456-9.
45-year-old man with the Acquired Immunodeficiency Syndrome, on highly active antiretroviral therapy (HAART) resulting in rapid decline of HIV RNA and increase of CD4 T cells count, developed multiple skin umbilicated lesions (resembling molluscum contagiosum) on his face, ears, neck and chest. Histopathology and mycological cultures of a skin biopsy revealed Cryptococcus neoformans. Antigens of Cryptococcus was also identified in blood. During treatment with amphotericin B, the skin lesions regressed. This case demonstrates that skin lesions resembling molluscum contagiosum may be caused by cryptococcal infection. It is necessary to perform skin biopsy in HIV-infected persons with skin lesions to diagnose cutaneous cryptococcosis. The open question is if skin cryptococcosis may be the immune reconstruction disease.
一名45岁患有获得性免疫缺陷综合征的男子，正在接受高效抗逆转录病毒治疗（HAART），该治疗导致HIV RNA迅速下降且CD4 T细胞计数增加，他的面部、耳朵、颈部和胸部出现了多个脐状皮肤病变（类似传染性软疣）。皮肤活检的组织病理学和真菌培养显示为新型隐球菌。血液中也检测到了隐球菌抗原。在用两性霉素B治疗期间，皮肤病变消退。该病例表明，类似传染性软疣的皮肤病变可能由隐球菌感染引起。对于有皮肤病变的HIV感染者，有必要进行皮肤活检以诊断皮肤隐球菌病。尚待解决的问题是皮肤隐球菌病是否可能是免疫重建疾病。
