Belgrave B E, Bird K D, Chesher G B, Jackson D M, Lubbe K E, Starmer G A, Teo R K
Psychopharmacology (Berl). 1979 Aug 8;64(2):243-6. doi: 10.1007/BF00496070.
Fifteen volunteers received cannabidiol (CBD) (320 microgram/kg) or placebo (both orally, T0), and 60 min later they consumed an ethanolic beverage (0.54 g/kg) or placebo. The effects were measured at T1 (100 min after CBD ingestion), T2 (160 min) and T3 (220 min) using cognitive, perceptual and motor function tests. Factorial analysis indicated that test procedures could be adequately expressed by three rotated factors: A reaction speed factor (I), a standing steadiness factor (II) and a psychomotor coordination/cognitive factor (III). Ethanol produced a significant decrement in factor III. There was no demonstrable effect of CBD, either alone or in combination with ethanol. Neither CBD nor ethanol produced any significant effect on pulse rate. Prior administration of CBD did not significantly affect the blood ethanol levels. Whilst the subjects were able to identify correctly when they were given ethanol, they did not report any subjective effects of CBD.
15名志愿者接受了大麻二酚（CBD）（320微克/千克）或安慰剂（均为口服，T0），60分钟后他们饮用了含酒精饮料（0.54克/千克）或安慰剂。在T1（摄入CBD后100分钟）、T2（160分钟）和T3（220分钟）使用认知、感知和运动功能测试来测量效果。因子分析表明，测试程序可以由三个旋转因子充分表达：反应速度因子（I）、站立稳定性因子（II）和心理运动协调/认知因子（III）。乙醇使因子III显著下降。CBD单独或与乙醇联合使用均未产生明显效果。CBD和乙醇对脉搏率均未产生任何显著影响。预先给予CBD对血液乙醇水平没有显著影响。虽然受试者能够正确识别何时给予了乙醇，但他们没有报告CBD的任何主观效果。
