Nishijima C, Sato S, Takehara K
Department of Dermatology, Kanazawa University School of Medicine, Japan.
J Rheumatol. 2001 Aug;28(8):1847-51.
To determine the prevalence and clinical correlations of anti-agalactosyl IgG antibodies (anti-AG IgG) in patients with systemic sclerosis (SSc).
Serum samples from patients with limited cutaneous SSc (lSSc; n = 49), diffuse cutaneous SSc (dSSc; n = 21), rheumatoid arthritis (RA; n = 10), systemic lupus erythematosus (SLE; n = 20), and healthy individuals (n = 20) were examined by lectin-enzyme immunoassay using human agalactosyl IgG as antigen.
Anti-AG IgG were detected in 52 (74%) of 70 patients with SSc, which was much higher than the frequency of rheumatoid factor positivity in SSc (16%). Levels of anti-agalactosyl IgG antibodies were significantly higher than in healthy controls or patients with SLE, but lower than patients with RA. Levels of anti-AG IgG in patients with dSSc were significantly higher than in lSSc. SSc patients with anti-topoisomerase I antibodies had significantly higher levels of anti-AG IgG than SSc patients with anticentromere antibodies. Concerning clinical correlation, patients with pulmonary fibrosis showed elevated levels of anti-AG IgG compared to those without pulmonary fibrosis. Patients with decreased %VC or %DLCO showed increased levels of anti-AG IgG. Elevated levels of anti-AG IgG were associated with the presence of contracture of phalanges or cutaneous calcinosis, but not the presence of arthritis/arthralgia.
The results suggest that anti-agalactosyl IgG antibody is frequently detected in SSc and is a serological indicator for more severe SSc.
确定系统性硬化症（SSc）患者中抗半乳糖基IgG抗体（抗AG IgG）的患病率及其临床相关性。
采用以人半乳糖基IgG为抗原的凝集素-酶免疫测定法，检测局限性皮肤型SSc（lSSc；n = 49）、弥漫性皮肤型SSc（dSSc；n = 21）、类风湿关节炎（RA；n = 10）、系统性红斑狼疮（SLE；n = 20）患者及健康个体（n = 20）的血清样本。
70例SSc患者中有52例（74%）检测到抗AG IgG，这一比例远高于SSc中类风湿因子阳性的频率（16%）。抗半乳糖基IgG抗体水平显著高于健康对照组或SLE患者，但低于RA患者。dSSc患者的抗AG IgG水平显著高于lSSc患者。抗拓扑异构酶I抗体阳性的SSc患者的抗AG IgG水平显著高于抗着丝点抗体阳性的SSc患者。关于临床相关性，与无肺纤维化的患者相比，肺纤维化患者的抗AG IgG水平升高。%VC或%DLCO降低的患者抗AG IgG水平升高。抗AG IgG水平升高与指骨挛缩或皮肤钙化的存在有关，但与关节炎/关节痛的存在无关。
结果表明，抗半乳糖基IgG抗体在SSc中经常被检测到，是更严重SSc的血清学指标。
