Huang S S, Tsai M C, Chih C L, Hung L M, Tsai S K
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei.
Life Sci. 2001 Jul 20;69(9):1057-65. doi: 10.1016/s0024-3205(01)01195-x.
Resveratrol is found in a wide variety of plant species. It is present in the seeds and skin of grapes and constitutes one of the major components of red wine. This study was undertaken to evaluate whether resveratrol could effectively suppress infarct size from the damaging effects of focal cerebral ischemia. The middle cerebral artery was occluded for 1 hr and 24 hr reperfusion in anesthetized Long-Evans rats. In pretreatment or treatment groups, resveratrol, at dosages of 10(-6), 10(-7), 10(-8) and 10(-9) g/kg, was intravenous injected 15 minutes before middle cerebral artery (MCA) occlusion or when the common carotid arteries clips were removed respectively. Pretreatment or treatment of resveratrol (10(-6), 10(-7), 10(-8) and 10(-9) g/kg) did not produce any changes in pH, blood gases, heart rate or mean arterial blood pressure, but it significantly reduced the total volume of infarction at the doses 10(-6) and 10(-7) g/kg. Our study suggests resveratrol is a potent neuroprotective agent in focal cerebral ischemia. Its beneficial effects may be related to its anti-platelet aggregation activity, vasodilating effect, antioxidant property or by all mechanisms together.
白藜芦醇存在于多种植物物种中。它存在于葡萄的种子和果皮中，是红酒的主要成分之一。本研究旨在评估白藜芦醇是否能有效抑制局灶性脑缺血损伤的梗死面积。在麻醉的Long-Evans大鼠中，大脑中动脉闭塞1小时并再灌注24小时。在预处理或治疗组中，分别在大脑中动脉（MCA）闭塞前15分钟或去除颈总动脉夹时，静脉注射剂量为10(-6)、10(-7)、10(-8)和10(-9) g/kg的白藜芦醇。白藜芦醇（10(-6)、10(-7)、10(-8)和10(-9) g/kg）的预处理或治疗对pH值、血气、心率或平均动脉血压没有产生任何变化，但在10(-6)和10(-7) g/kg剂量时显著降低了梗死总体积。我们的研究表明，白藜芦醇在局灶性脑缺血中是一种有效的神经保护剂。其有益作用可能与其抗血小板聚集活性、血管舒张作用、抗氧化特性或所有机制共同作用有关。
