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意外接触乙撑亚胺后气管支气管软骨的损伤与修复

Injury and repair of tracheobronchial cartilage following accidental exposure to ehtyleneimine.

作者信息

Gresham G A, West I E

出版信息

J Clin Pathol. 1975 Jul;28(7):564-7. doi: 10.1136/jcp.28.7.564.

DOI:10.1136/jcp.28.7.564
PMID:1150896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC475772/
Abstract

A fatal case following ehtyleneimine inhalation is described. Profound destructive effects on tracheobronchial cartilage were found at necropsy after an interval of apparent recovery from early phases of poisoning. The pathogenesis of these cartilaginous changes is discussed. It is proposed that they may have been due to proteases liberated from liberated from mucosal granulation tissue.

摘要

本文描述了一例因吸入乙撑亚胺而致死的病例。在中毒早期看似恢复后的一段时间，尸检发现气管支气管软骨受到严重破坏。文中讨论了这些软骨变化的发病机制。有人提出，它们可能是由于从黏膜肉芽组织释放出的蛋白酶所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/cad1a3e1b2df/jclinpath00141-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/4999e54dc025/jclinpath00141-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/1c0d92330df0/jclinpath00141-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/cad1a3e1b2df/jclinpath00141-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/4999e54dc025/jclinpath00141-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/1c0d92330df0/jclinpath00141-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5c/475772/cad1a3e1b2df/jclinpath00141-0050-a.jpg

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本文引用的文献

1
ACCIDENTAL EXPOSURE TO ETHYLENIMINE AND N-ETHYLETHYLENIMINE VAPORS.
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Diffuse perichondritis, chondritis, and iritis; report of an autopsied case.
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Reversible collapse of rabbit ears after intravenous papain, and prevention of recovery by cortisone.静脉注射木瓜蛋白酶后兔耳的可逆性塌陷，以及可的松对恢复的预防作用。
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Thorax. 1979 Aug;34(4):563-4. doi: 10.1136/thx.34.4.563.
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Healing in cartilage.软骨修复
Surg Gynecol Obstet. 1973 Dec;137(6):953-5.
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Nuclear fibrous lamina in pathological human synovial membrane.
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The biochemistry and function of mucosubstances.
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