Du J, Wang M L, Chen R Y, Yu D Q
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Planta Med. 2001 Aug;67(6):542-7. doi: 10.1055/s-2001-16491.
Two new bislabdane-type diterpenoids lanceolatin (1), lancelatol (2) and three new diterpenoids 15-nor-14-oxo-8(17),12-labdanien-14,18-dionic acid (3), 8(17),12,14-labdantrien-18-oic acid (4) and 8(17),12,14-labdantrien-18-ol (5), together with 7 known diterpenoids were isolated from the roots of Cunninghamia lanceolata. Their structures were determined by spectroscopic and chemical methods. All of these compounds were isolated from the species for the first time. One of the isolated compounds showed a significant inhibition effect on mouse hind-paw edema induced by carrageenan.
从杉木根中分离得到两个新的双-labdane型二萜类化合物披针叶杉素（1）、披针叶杉醇（2）以及三个新的二萜类化合物15-降-14-氧代-8(17),12-labdanien-14,18-二酸（3）、8(17),12,14-labdantrien-18-酸（4）和8(17),12,14-labdantrien-18-醇（5），以及7个已知的二萜类化合物。通过光谱和化学方法确定了它们的结构。所有这些化合物均首次从该物种中分离得到。其中一个分离得到的化合物对角叉菜胶诱导的小鼠后爪水肿具有显著的抑制作用。
