相思豆根中的潜在抗炎二萜
Potential anti-inflammatory diterpenoids from the roots of Caesalpinia mimosoides Lamk.
机构信息
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
出版信息
Phytochemistry. 2010 Oct;71(14-15):1756-64. doi: 10.1016/j.phytochem.2010.06.016. Epub 2010 Jul 23.
Anti-inflammatory assay-guided separation of extracts from the roots of Caesalpinia mimosoides Lamk. led to isolation of seven compounds: four diterpenes (1-4), a dimer (9), and two dibenzo[b,d]furans (10, 11) together with eleven known compounds. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR, mass spectral data and comparison with literature values. The anti-inflammatory activities of all compounds were evaluated for inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Compounds 4, 6, 8, and 12-14 were also tested for the inhibitory effect on LPS-induced tumor necrosis factor-alpha (TNF-alpha) release in RAW264.7 cells. The results indicated that 4 possessed potent inhibitory activity for both tests with IC(50) values of 3.0 and 6.5 microM, respectively.
抗炎活性导向分离金凤花（Caesalpinia mimosoides Lamk.）根提取物，得到七种化合物：四个二萜（1-4），一个二聚体（9），和两个苯并[b,d]呋喃（10,11），以及 11 个已知化合物。通过 1D-和 2D-NMR 技术以及 UV、IR、质谱数据并与文献值比较，确定了它们的结构。所有化合物的抗炎活性均通过抑制 RAW264.7 细胞系中脂多糖（LPS）诱导的一氧化氮（NO）产生来评估。还测试了化合物 4,6,8 和 12-14 对 LPS 诱导的 RAW264.7 细胞肿瘤坏死因子-α（TNF-α）释放的抑制作用。结果表明，化合物 4 在这两项测试中均具有很强的抑制活性，IC50 值分别为 3.0 和 6.5 microM。
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