Wooten G, Hanson T, Lamprecht F
J Neural Transm. 1975;36(2):107-12. doi: 10.1007/BF01256758.
The activity of dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to norepinephrine, was measured in the serum of a strain of Wistar rats homozygous and heterozygous for a genetic form of hypothalamic diabetes insipidus and in Wistar control rats. Serum dopamine-beta-hydroxylase activity and water intake was highest in the homozygous affected rats and lowest in normal controls. Treatment with pitressin tannate reduced serum enzyme activity and water intake in rats with diabetes insipidus to levels which did not differ from controls. Thus serum dopamine-beta-hydroxylase activity appeared to vary directly with changes in sympathetic nerve activity in response to intravascular volume depletion and repletion.
在一种遗传性下丘脑性尿崩症的纯合子和杂合子Wistar大鼠品系的血清中，以及在Wistar对照大鼠中，测量了多巴胺-β-羟化酶（催化多巴胺转化为去甲肾上腺素的酶）的活性。纯合子患病大鼠的血清多巴胺-β-羟化酶活性和饮水量最高，而正常对照组最低。用鞣酸加压素治疗可使尿崩症大鼠的血清酶活性和饮水量降低至与对照组无差异的水平。因此，血清多巴胺-β-羟化酶活性似乎与交感神经活动因血管内容量减少和补充而发生的变化直接相关。
