Song E, Chen J, Ou Q, Su F
Department of Surgery, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University of Medical Science, 107, Yanjiang West Road, 510120, Guangzhou, China.
Am J Surg. 2001 Jun;181(6):529-33. doi: 10.1016/s0002-9610(01)00634-1.
It has been demonstrated that colorectal carcinomas rarely metastasize to diseased livers. However, this phenomenon has not been thoroughly evaluated in patients with various forms of chronic hepatitis B virus (HBV) infection. Therefore, the present study examined the relationship between the incidence of hepatic metastasis of colorectal carcinomas and chronic HBV infection, with emphasis on the influence of HBV viral replication and chronic liver damage.
We analyzed the clinicopathological data of 512 patients undergoing surgical treatment of colorectal carcinomas at our department from 1992 to 1998. Among these cases, 74 had chronic HBV infection, including 28 cases with HBV replication and 21 with chronic liver damage.
The incidence of liver metastasis in the HBV infection group (13.5%) was significantly lower than that of the noninfection group (27.1%, P <0.05). In addition, patients with HBV infection survived longer than those without infection (P = 0.018). Furthermore, liver metastatic rate in patients with HBV replication (3.6%) was lower than those without virus replication (19.6%, P <0.05). In contrast, there was no significant difference in liver metastasis between HBV infected patients with or without chronic liver damage (P >0.05).
Chronic HBV infection with viral replication reduces hepatic metastasis of colorectal cancer, and thus prolongs the survival of patients.
已证实结直肠癌很少转移至患病肝脏。然而，在各种形式的慢性乙型肝炎病毒（HBV）感染患者中，这一现象尚未得到充分评估。因此，本研究探讨了结直肠癌肝转移发生率与慢性HBV感染之间的关系，重点关注HBV病毒复制和慢性肝损伤的影响。
我们分析了1992年至1998年在我科接受结直肠癌手术治疗的512例患者的临床病理资料。其中，74例有慢性HBV感染，包括28例HBV复制患者和21例慢性肝损伤患者。
HBV感染组的肝转移发生率（13.5%）显著低于未感染组（27.1%，P<0.05）。此外，HBV感染患者的生存期比未感染患者更长（P = 0.018）。此外，HBV复制患者的肝转移率（3.6%）低于无病毒复制患者（19.6%，P<0.05）。相比之下，有无慢性肝损伤的HBV感染患者在肝转移方面无显著差异（P>0.05）。
伴有病毒复制的慢性HBV感染可降低结直肠癌的肝转移，从而延长患者生存期。
