Qian Hong-gang, Zhang Ji, Leng Jia-hua, Zhou Guo-quan, Wu Jian-hui, Tian Xiu-yun, Yang Yong, Hao Chun-yi
Department of Surgery, Peking University School of Oncology, Beijing 100142, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Mar;13(3):202-4.
To explore the relationship of hepatitis B virus (HBV) infection and cirrhosis with liver metastasis in colorectal cancer.
Clinical date of 1176 colorectal cancer patients undergone surgical treatment in the Peking University School of Oncology between January 1999 and August 2004 were analyzed retrospectively to investigate the impact of HBV infection and cirrhosis on the occurrence of liver metastasis and prognosis of patients.
The incidence of liver metastasis was 8.8% (10/114) in the HBV infection group and 23.9% (254/1062) in the non-infection group (P<0.01). The 5-year survival rates of these two groups were 54.2% and 60.7% ( P>0.05). The incidence of liver metastasis was 3.8% (1/26) in the cirrhotic group and 22.9% (263/1150) in the non-cirrhotic group (P<0.05). The 5-year survival rates of these two groups were 60.9% and 59.9% ( P>0.05).
Both hepatitis B virus infection and cirrhosis are associated with less liver metastasis in colorectal cancer, but have no impact on the survival.
探讨乙型肝炎病毒（HBV）感染及肝硬化与结直肠癌肝转移的关系。
回顾性分析1999年1月至2004年8月在北京大学肿瘤医院接受手术治疗的1176例结直肠癌患者的临床资料，以研究HBV感染及肝硬化对患者肝转移发生情况及预后的影响。
HBV感染组肝转移发生率为8.8%（10/114），非感染组为23.9%（254/1062）（P<0.01）。两组的5年生存率分别为54.2%和60.7%（P>0.05）。肝硬化组肝转移发生率为3.8%（1/26），非肝硬化组为22.9%（263/1150）（P<0.05）。两组的5年生存率分别为60.9%和59.9%（P>0.05）。
乙型肝炎病毒感染和肝硬化均与结直肠癌肝转移较少有关，但对生存率无影响。
