Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Bioengineered. 2021 Dec;12(1):736-744. doi: 10.1080/21655979.2021.1890871.
The paper aims to assess the association between Hepatitis B Virus infection and colorectal liver metastasis by conducting a meta-analysis. The relevant studies were searched until 24 July 2020, Studies that assessed the correlation between HBV infection and CRLM were recruited. A random effects model was applied to calculate the odds ratio (OR) with 95% confidence interval (CI). All data analyses were performed by STATA 12.0 software. Ten studies involving 17529 participants were included in the study. The results shown that there was obvious association between HBV infection and CRLM (OR: 0.51, 95% CI: 0.28-0.91). The study type and case-control rate may be the main causes of heterogeneity. In addition, HBV infection had no association with extrahepatic metastasis or prognosis of patients with CRLM. Sensitivity analyses confirmed that the results were stable, and Egg's test indicated that there was no publication bias. Patients with HBV infection have the reduced risk of CRLM.
本研究旨在通过荟萃分析评估乙型肝炎病毒（HBV）感染与结直肠癌肝转移（CRLM）的相关性。检索截至 2020 年 7 月 24 日的相关研究，纳入评估 HBV 感染与 CRLM 相关性的研究。采用随机效应模型计算比值比（OR）及其 95%置信区间（CI）。所有数据分析均采用 STATA 12.0 软件进行。研究共纳入 10 项、17529 例参与者的研究。结果表明，HBV 感染与 CRLM 明显相关（OR：0.51，95%CI：0.28-0.91）。研究类型和病例对照率可能是异质性的主要原因。此外，HBV 感染与 CRLM 患者的肝外转移或预后无关。敏感性分析证实结果稳定，Egg 检验表明无发表偏倚。HBV 感染者 CRLM 的风险降低。
