Daiyasu H, Osaka K, Ishino Y, Toh H
Department of Bioinformatics, Biomolecular Engineering Research Institute, Osaka, Japan.
FEBS Lett. 2001 Aug 10;503(1):1-6. doi: 10.1016/s0014-5793(01)02686-2.
Recently, the zinc metallo-hydrolase family of the beta-lactamase fold has grown quite rapidly, accompanied by the accumulation of sequence and structure data. The variety of the biological functions of the family is higher than expected. In addition, the members often have mosaic structures with additional domains. The family includes class B beta-lactamase, glyoxalase II, arylsulfatase, flavoprotein, cyclase/dehydrase, an mRNA 3'-processing protein, a DNA cross-link repair enzyme, a DNA uptake-related protein, an alkylphosphonate uptake-related protein, CMP-N-acetylneuraminate hydroxylase, the romA gene product, alkylsulfatase, and insecticide hydrolases. In this minireview, the functional and structural varieties of the growing protein family are described.
最近，具有β-内酰胺酶折叠结构的锌金属水解酶家族发展迅速，同时伴随着序列和结构数据的积累。该家族的生物学功能多样性高于预期。此外，其成员通常具有带有额外结构域的嵌合结构。该家族包括B类β-内酰胺酶、乙二醛酶II、芳基硫酸酯酶、黄素蛋白、环化酶/脱水酶、一种mRNA 3'-加工蛋白、一种DNA交联修复酶、一种DNA摄取相关蛋白、一种烷基膦酸盐摄取相关蛋白、CMP-N-乙酰神经氨酸羟化酶、romA基因产物、烷基硫酸酯酶和杀虫剂水解酶。在这篇小型综述中，描述了这个不断发展的蛋白质家族的功能和结构多样性。
