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本文引用的文献

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A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.一种发挥作用的金属β-内酰胺酶：单锌碳青霉烯酶CphA的晶体结构及其与比阿培南的复合物
J Mol Biol. 2005 Jan 28;345(4):785-95. doi: 10.1016/j.jmb.2004.10.070.
2
Independent origins of subgroup Bl + B2 and subgroup B3 metallo-beta-lactamases.
J Mol Evol. 2004 Jul;59(1):133-41. doi: 10.1007/s00239-003-2572-9.
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Comparison of two crystal structures of TGF-beta2: the accuracy of refined protein structures.
Acta Crystallogr D Biol Crystallogr. 1994 Jan 1;50(Pt 1):85-92. doi: 10.1107/S090744499300808X.
4
Update of the standard numbering scheme for class B beta-lactamases.B类β-内酰胺酶标准编号方案的更新。
Antimicrob Agents Chemother. 2004 Jul;48(7):2347-9. doi: 10.1128/AAC.48.7.2347-2349.2004.
5
Evolution of the serine beta-lactamases: past, present and future.丝氨酸β-内酰胺酶的演变：过去、现在与未来
Drug Resist Updat. 2004 Apr;7(2):111-23. doi: 10.1016/j.drup.2004.02.003.
6
On the evolution of structure in aminoacyl-tRNA synthetases.氨酰-tRNA合成酶结构的演变
Microbiol Mol Biol Rev. 2003 Dec;67(4):550-73. doi: 10.1128/MMBR.67.4.550-573.2003.
7
Structure-based phylogenies of the serine beta-lactamases.基于结构的丝氨酸β-内酰胺酶系统发育树
J Mol Evol. 2003 Sep;57(3):255-60. doi: 10.1007/s00239-003-2473-y.
8
The metallo-beta-lactamases fall into two distinct phylogenetic groups.金属β-内酰胺酶可分为两个不同的系统发育组。
J Mol Evol. 2003 Sep;57(3):249-54. doi: 10.1007/s00239-003-2471-0.
9
Structure-based phylogenetic analysis of short-chain alcohol dehydrogenases and reclassification of the 17beta-hydroxysteroid dehydrogenase family.基于结构的短链醇脱氢酶系统发育分析及17β-羟基类固醇脱氢酶家族的重新分类
Mol Biol Evol. 2001 Dec;18(12):2154-61. doi: 10.1093/oxfordjournals.molbev.a003761.
10
Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold.β-内酰胺酶折叠结构的锌金属水解酶家族的扩展。
FEBS Lett. 2001 Aug 10;503(1):1-6. doi: 10.1016/s0014-5793(01)02686-2.

基于结构的金属β-内酰胺酶系统发育学

Structure-based phylogeny of the metallo-beta-lactamases.

作者信息

Garau Gianpiero, Di Guilmi Anne Marie, Hall Barry G

机构信息

Laboratoire de Cristallographie Macromoléulaire, Institut de Biologie Structural Jean-Pierre Ebel, CEA-CNRS-UJF, Grenoble, France.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):2778-84. doi: 10.1128/AAC.49.7.2778-2784.2005.

DOI:10.1128/AAC.49.7.2778-2784.2005
PMID:15980349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168685/
Abstract

The metallo-beta-lactamases fall into two groups: Ambler class B subgroups B1 and B2 and Ambler class B subgroup B3. The two groups are so distantly related that there is no detectable sequence homology between members of the two different groups, but homology is clearly detectable at the protein structure level. The multiple structure alignment program MAPS has been used to align the structures of eight metallo-beta-lactamases and five structurally homologous proteins from the metallo-beta-lactamase superfamily, and that alignment has been used to construct a phylogenetic tree of the metallo-beta-lactamases. The presence of genes from Eubacteria, Archaebacteria, and Eukaryota on that tree is consistent with a very ancient origin of the metallo-beta-lactamase family.

摘要

金属β-内酰胺酶分为两组：安布勒B类亚组B1和B2以及安布勒B类亚组B3。这两组的亲缘关系非常远，以至于两个不同组的成员之间没有可检测到的序列同源性，但在蛋白质结构水平上同源性是明显可检测到的。多重结构比对程序MAPS已被用于比对八种金属β-内酰胺酶和来自金属β-内酰胺酶超家族的五种结构同源蛋白的结构，并且该比对已被用于构建金属β-内酰胺酶的系统发育树。该树上存在来自真细菌、古细菌和真核生物的基因，这与金属β-内酰胺酶家族非常古老的起源是一致的。