Wang Jingyuan, Yang Xiao, Wang Zhiqi, Wang Jianliu
Peking University People's Hospital, Beijing, China.
Front Oncol. 2022 Jul 8;12:857746. doi: 10.3389/fonc.2022.857746. eCollection 2022.
Methyglyoxal (MGO), an essential endogenous dicarbonyl metabolite, can lead to multiple physiological problems including hyperglycemia, kidney diseases, malignant tumors, beyond its normal concentration range. The glyoxalase system, making MGO maintained at a low level, links glycation to carcinogenesis, growth, metastasis, and cancer chemotherapy. The glyoxalase system comprises glyoxalase 1 (Glo1) and glyoxalase 2 (Glo2), which is often overexpressed in various tumor tissues. However, very little is known about the glyoxalase system in breast cancer and gynecological cancer. In this review, we introduce the role of the glyoxalase system in breast cancer, endometrial cancer, ovarian cancer and cervical cancer, and highlight the potential of the glyoxalase system to be both as a marker for diagnosis and a novel target for antitumor therapy. However, the intrinsic molecular biology and mechanisms of the glyoxalase system in breast cancer and gynecological cancer need further exploration.
甲基乙二醛（MGO）是一种重要的内源性二羰基代谢产物，当其超出正常浓度范围时，可引发多种生理问题，包括高血糖、肾脏疾病和恶性肿瘤等。乙二醛酶系统可使MGO维持在低水平，它将糖基化与肿瘤发生、生长、转移及癌症化疗联系起来。乙二醛酶系统由乙二醛酶1（Glo1）和乙二醛酶2（Glo2）组成，该系统在多种肿瘤组织中常过度表达。然而，关于乳腺癌和妇科癌症中的乙二醛酶系统，人们了解甚少。在本综述中，我们介绍了乙二醛酶系统在乳腺癌、子宫内膜癌、卵巢癌和宫颈癌中的作用，并强调了乙二醛酶系统作为诊断标志物和抗肿瘤治疗新靶点的潜力。然而，乳腺癌和妇科癌症中乙二醛酶系统的内在分子生物学及机制仍需进一步探索。
