Morrow Lisa A, Scott Allene
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania n15213, USA.
Appl Neuropsychol. 2002;9(4):240-3. doi: 10.1207/S15324826AN0904_7.
The purpose of this study was to determine whether men and women with a history of similar exposure to organic solvents demonstrate differences in neuropsychological performance. An equal number of men and women were compared on a battery of neuropsychological tests. Men and women were matched on age, education, and past history of exposure (i.e., length of exposure, recency of exposure, and history of peak exposure). With the exception of 1 test, there were no differences between men and women on any of the cognitive tests. There were also no differences in self-reported psychological symptoms. There was, however, a different pattern of correlations between test scores and exposure for the men and women: In women, exposure was associated with tests of attention and processing speed, whereas in men, exposure was associated with verbal memory. After controlling for age and education, the findings were diminished for men but remained significant for women. Overall, the results show no differences in neuropsychological test scores between men and women when matched on exposure variables but raise the possibility of differences in the pattern of cognitive deficits associated with solvent exposure between men and women.
本研究的目的是确定有相似有机溶剂接触史的男性和女性在神经心理表现上是否存在差异。在一系列神经心理测试中对相同数量的男性和女性进行了比较。男性和女性在年龄、教育程度和既往接触史（即接触时长、最近接触情况和最高接触史）方面进行了匹配。除一项测试外，在任何认知测试中男性和女性之间均无差异。自我报告的心理症状也没有差异。然而，男性和女性的测试分数与接触之间存在不同的相关模式：在女性中，接触与注意力和处理速度测试相关，而在男性中，接触与言语记忆相关。在控制年龄和教育程度后，男性的研究结果减弱，但对女性而言仍具有显著性。总体而言，结果表明，在接触变量匹配的情况下，男性和女性在神经心理测试分数上没有差异，但增加了男性和女性与溶剂接触相关的认知缺陷模式存在差异的可能性。
