Molero A E, Pino-Ramírez G, Maestre G E
Institute for Biological Research and Cardiovascular Center, Faculty of Medicine, University of Zulia, Apdo. Postal 10.636, Maracaibo 4002-a, Venezuela.
Neurosci Lett. 2001 Jul 6;307(1):5-8. doi: 10.1016/s0304-3940(01)01911-5.
An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one epsilon4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-epsilon4, adjusted for age and stratified by gender, was significant only for women. No association was found between the epsilon-2 allele and AD or VD. The results support the notions that APOE-epsilon4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.
在委内瑞拉马拉开波进行的一项正在进行的纵向研究，考察了载脂蛋白E（APOE）基因与阿尔茨海默病（AD）和血管性痴呆（VD）之间的相互作用，并将年龄和性别作为风险的潜在调节因素进行评估。总体而言，至少携带一个ε4等位基因的个体患AD的风险较高，而非VD；然而，该风险仅在65岁以上的受试者中显著，在85岁以上的受试者中增加了10倍。经年龄调整并按性别分层后，APOE-ε4赋予的AD风险仅在女性中显著。未发现ε2等位基因与AD或VD之间存在关联。这些结果支持以下观点：APOE-ε4与晚发性而非早发性AD相关，且年龄和性别是这种关联的调节因素。
