中枢儿茶酚胺改变对去甲丙咪嗪治疗大鼠低温反应的影响。 6-羟基多巴胺的作用
Effect of central catecholamine alterations on the hypothermic response to 6-hydroxydopamine in desipramine treated rats.
作者信息
Breese G R, Howard J L
出版信息
Br J Pharmacol. 1971 Nov;43(3):671-4. doi: 10.1111/j.1476-5381.1971.tb07197.x.
Abstract
The hypothermia observed in rats kept in a cold environment after the intracisternal administration of 6-hydroxydopamine was enhanced by desipramine. Since pretreatment with 6-hydroxydopamine virtually eliminated the temperature fall in response to a subsequent dose of 6-hydroxydopamine, brain catecholamines were implicated in the response. Preferential reduction of brain noradrenaline antagonized the hypothermia after 6-hydroxydopamine in desipramine-treated rats to a greater extent than did the preferential reduction of dopamine. The results indicate the importance of noradrenergic fibres in this hypothermic response, but do not exclude an involvement of brain dopaminergic pathways.
摘要
脑室内注射6-羟基多巴胺后，置于寒冷环境中的大鼠出现体温过低，而地昔帕明可增强这种低温状态。由于预先用6-羟基多巴胺处理实际上消除了后续剂量的6-羟基多巴胺引起的体温下降，因此认为脑儿茶酚胺与该反应有关。与优先降低多巴胺相比，优先降低脑去甲肾上腺素在更大程度上拮抗了地昔帕明处理的大鼠注射6-羟基多巴胺后的体温过低。结果表明去甲肾上腺素能纤维在这种低温反应中很重要，但不排除脑多巴胺能通路的参与。
相似文献
1
Effect of central catecholamine alterations on the hypothermic response to 6-hydroxydopamine in desipramine treated rats.中枢儿茶酚胺改变对去甲丙咪嗪治疗大鼠低温反应的影响。 6-羟基多巴胺的作用
Br J Pharmacol. 1971 Nov;43(3):671-4. doi: 10.1111/j.1476-5381.1971.tb07197.x.
2
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.用6-羟基多巴胺耗尽脑内去甲肾上腺素和多巴胺。
Br J Pharmacol. 1971 May;42(1):88-99. doi: 10.1111/j.1476-5381.1971.tb07089.x.
3
Altered effects of desipramine on operant performance after 6-hydroxydopamine-induced depletion of brain dopamine or norepinephrine.6-羟基多巴胺诱导脑内多巴胺或去甲肾上腺素耗竭后，地昔帕明对操作性行为表现的影响改变。
J Pharmacol Exp Ther. 1984 Jun;229(3):629-35.
4
Central effects of 6-hydroxydopamine on the body temperature of the rat.6-羟基多巴胺对大鼠体温的中枢作用。
Br J Pharmacol. 1970 Dec;40(4):630-8. doi: 10.1111/j.1476-5381.1970.tb10643.x.
5
The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6-hydroxydopamine in rats.诺米芬辛对大鼠中分别由芬氟拉明和6-羟基多巴胺诱导的脑5-羟色胺和儿茶酚胺耗竭的影响。
Eur J Pharmacol. 1975 Dec;34(2):377-80. doi: 10.1016/0014-2999(75)90266-6.
6
Central actions of 6-hydroxydopamine and other phenylethylamine derivatives on body temperature in the rat.6-羟基多巴胺及其他苯乙胺衍生物对大鼠体温的中枢作用
J Pharmacol Exp Ther. 1972 Mar;180(3):591-602.
7
Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants.抗抑郁药证明去甲肾上腺素能神经元参与小鼠脑室内注射6-羟基多巴胺诱导的体温过低。
J Neural Transm. 1988;74(1):17-27. doi: 10.1007/BF01243572.
8
6-Hydroxydopamine-induced blockade of hypothalamic obesity: critical role of brain dopamine-norepinephrine interaction.6-羟基多巴胺诱导的下丘脑性肥胖阻断：脑多巴胺-去甲肾上腺素相互作用的关键作用
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):369-72. doi: 10.1016/s0278-5846(82)80109-7.
9
Eating caused by 6-hydroxydopamine-induced release of noradrenaline in the diencephalon of the rat.6-羟基多巴胺诱导大鼠间脑中去甲肾上腺素释放所引发的进食行为。
J Physiol. 1972 May;223(1):35-47. doi: 10.1113/jphysiol.1972.sp009832.
10
Catecholamine release by intracerebral perfusion of 6-hydroxydopamine and desipramine.通过脑室内灌注6-羟基多巴胺和地昔帕明释放儿茶酚胺。
Eur J Pharmacol. 1976 Apr;36(2):299-311. doi: 10.1016/0014-2999(76)90083-2.
引用本文的文献
1
Novel human reovirus isolated from children and its long-term circulation with reassortments.从儿童中分离出的新型人类呼肠孤病毒及其长期重组传播。
Sci Rep. 2020 Jan 22;10(1):963. doi: 10.1038/s41598-020-58003-9.
2
Further evidence for a physiological role for hypothalamic dopamine in thermoregulation in the rat.关于下丘脑多巴胺在大鼠体温调节中生理作用的进一步证据。
J Physiol. 1980 Mar;300:7-17. doi: 10.1113/jphysiol.1980.sp013147.
3
Acute thermoregulatory and cardiovascular effects of 6-hydroxydopamine administered centrally in rabbits and cats.6-羟基多巴胺经兔和猫中枢给药后的急性体温调节和心血管效应。
Br J Pharmacol. 1972 Nov;46(3):559P-560P.
4
Enhanced behavioral depressant effects of reserpine and -methyltyrosine after 6-hydroxydopamine treatment.6-羟基多巴胺处理后利血平和α-甲基酪氨酸的行为抑制作用增强。
Psychopharmacologia. 1972;27(2):99-110. doi: 10.1007/BF00439368.
5
The ineffectiveness of desipramine pretreatment on behavioral effects of 6-hydroxydopamine in nialamide-pretreated rats.去甲丙咪嗪预处理对烟酰胺预处理大鼠中6-羟基多巴胺行为效应的无效性。
Psychopharmacologia. 1974;38(2):173-80. doi: 10.1007/BF00426111.
6
The effects of intraventricular 6-hydroxydopamine on body temperature and arterial blood pressure in cats and rabbits.脑室内注射6-羟基多巴胺对猫和兔体温及动脉血压的影响。
Br J Pharmacol. 1974 Jun;51(2):207-12. doi: 10.1111/j.1476-5381.1974.tb09648.x.
7
Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants.抗抑郁药证明去甲肾上腺素能神经元参与小鼠脑室内注射6-羟基多巴胺诱导的体温过低。
J Neural Transm. 1988;74(1):17-27. doi: 10.1007/BF01243572.
本文引用的文献
1
Effect of psychotropic drugs on the uptake of H3-norepinephrine by tissues.精神药物对组织摄取H3-去甲肾上腺素的影响。
Science. 1961 Feb 10;133(3450):383-4. doi: 10.1126/science.133.3450.383.
2
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.用6-羟基多巴胺耗尽脑内去甲肾上腺素和多巴胺。
Br J Pharmacol. 1971 May;42(1):88-99. doi: 10.1111/j.1476-5381.1971.tb07089.x.
3
Central effects of 6-hydroxydopamine on the body temperature of the rat.6-羟基多巴胺对大鼠体温的中枢作用。
Br J Pharmacol. 1970 Dec;40(4):630-8. doi: 10.1111/j.1476-5381.1970.tb10643.x.
4
Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.6-羟基多巴胺对脑去甲肾上腺素和多巴胺的影响：儿茶酚胺能神经元选择性变性的证据
J Pharmacol Exp Ther. 1970 Sep;174(3):413-20.
5
Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat.普罗替林对6-羟基多巴胺诱导的大鼠脑内儿茶酚胺耗竭的影响。
J Pharm Pharmacol. 1970 Jul;22(7):540-3. doi: 10.1111/j.2042-7158.1970.tb10564.x.
Zotero 插件