Breese G R, Howard J L
Br J Pharmacol. 1971 Nov;43(3):671-4. doi: 10.1111/j.1476-5381.1971.tb07197.x.
The hypothermia observed in rats kept in a cold environment after the intracisternal administration of 6-hydroxydopamine was enhanced by desipramine. Since pretreatment with 6-hydroxydopamine virtually eliminated the temperature fall in response to a subsequent dose of 6-hydroxydopamine, brain catecholamines were implicated in the response. Preferential reduction of brain noradrenaline antagonized the hypothermia after 6-hydroxydopamine in desipramine-treated rats to a greater extent than did the preferential reduction of dopamine. The results indicate the importance of noradrenergic fibres in this hypothermic response, but do not exclude an involvement of brain dopaminergic pathways.
脑室内注射6-羟基多巴胺后，置于寒冷环境中的大鼠出现体温过低，而地昔帕明可增强这种低温状态。由于预先用6-羟基多巴胺处理实际上消除了后续剂量的6-羟基多巴胺引起的体温下降，因此认为脑儿茶酚胺与该反应有关。与优先降低多巴胺相比，优先降低脑去甲肾上腺素在更大程度上拮抗了地昔帕明处理的大鼠注射6-羟基多巴胺后的体温过低。结果表明去甲肾上腺素能纤维在这种低温反应中很重要，但不排除脑多巴胺能通路的参与。
