18F 标记的潜在心肌血流示踪剂的合成与性质
Synthesis and properties of 18F-labeled potential myocardial blood flow tracers.
作者信息
Studenov A R, Berridge M S
机构信息
Department of Chemistry, Case Western Reserve University, University Hospital of Cleveland, Cleveland, OH 44106, USA.
出版信息
Nucl Med Biol. 2001 Aug;28(6):683-93. doi: 10.1016/s0969-8051(01)00233-5.
PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced 82Rb(+) and 62Cu[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have synthesized several 18F-labeled amines and quaternary ammonium salts. Among them, 4-[18F]fluorotri-N-methylanilinium ([18F]FTMA) has flow-tracing properties. The compound is functional, but has properties that justify a continued search.
没有粒子加速器的正电子发射断层扫描（PET）中心以降低的成本使临床PET广泛可用。对于心肌灌注示踪剂，这些卫星PET中心仅限于由发生器产生的82Rb(+)和62Cu[PTSM]。它们的局限性促使人们寻找可运输的替代物。为了寻找新的示踪剂，我们合成了几种18F标记的胺和季铵盐。其中，4-[18F]氟三-N-甲基苯胺鎓（[18F]FTMA）具有血流示踪特性。该化合物具有功能性，但具有值得继续探索的特性。
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