Breadmore M C, Haddad P R
Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart.
Electrophoresis. 2001 Aug;22(12):2464-89. doi: 10.1002/1522-2683(200107)22:12<2464::AID-ELPS2464>3.0.CO;2-U.
One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high-performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on-line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on-line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.
毛细管电泳（CE）发展面临的主要问题之一是，与传统的高效液相色谱（HPLC）方法相比，其检测限相对较高。虽然使用替代检测器可以提供更好的灵敏度，但更通用的方法是样品预浓缩。已经开发了许多在线方法来提高CE的灵敏度，这些方法基于电泳原理、色谱原理或两者的结合。本文将讨论CE的各种在线预浓缩方法，重点关注那些在应用于无机和小有机阴离子时表现出特别优点的方法。
