恶性疟原虫这种毒性很强的人类疟原虫具有非常大的长期有效种群规模。
Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.
作者信息
Hughes A L, Verra F
机构信息
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
出版信息
Proc Biol Sci. 2001 Sep 7;268(1478):1855-60. doi: 10.1098/rspb.2001.1759.
Abstract
It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum-likelihood methods yielded the conclusion that the effective population size of this species has been of the order of at least 10(5) for the past 300,000-400,000 years.
摘要
有人提出，恶性人类疟原虫——恶性疟原虫最近经历了一次严重的种群瓶颈。为了验证这一假设，我们使用了基于溯祖理论的多种方法，根据23个核蛋白编码位点的核苷酸替换模式，估计了该物种的有效种群大小。简单方法和基于系统发育的最大似然法均得出结论，在过去30万至40万年里，该物种的有效种群大小至少达到了10^5数量级。
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