Joy Deirdre A, Feng Xiaorong, Mu Jianbing, Furuya Tetsuya, Chotivanich Kesinee, Krettli Antoniana U, Ho May, Wang Alex, White Nicholas J, Suh Edward, Beerli Peter, Su Xin-zhuan
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
Science. 2003 Apr 11;300(5617):318-21. doi: 10.1126/science.1081449.
The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, followed by migration to other regions on the basis of variation in 100 worldwide mitochondrial DNA sequences. However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings.
最近有人提出假设，在过去6000年里，由于人类行为和蚊子传播的一系列变化，非洲出现了恶性疟原虫。在此，我们基于全球100个线粒体DNA序列的变异，提供了约1万年前非洲疟原虫种群突然增加的遗传证据，随后疟原虫迁移到了其他地区。然而，全球和一些区域的种群似乎更古老（5万至10万岁），这表明可能在更新世人类迁徙期间，就已经有一波早期的迁徙浪潮离开了非洲。
