醛糖还原酶抑制剂CP - 45,634对糖尿病和半乳糖血症大鼠多元醇途径活性的抑制作用。 - Suppr | 超能文献

Inhibition of polyol pathway activity in diabetic and galactosemic rats by the aldose reductase inhibitor CP-45,634.

作者信息

Peterson M J, Sarges R, Aldinger C E, MacDonald D P

出版信息

Adv Exp Med Biol. 1979;119:347-56. doi: 10.1007/978-1-4615-9110-8_51.

DOI:10.1007/978-1-4615-9110-8_51

Abstract

摘要

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Inhibition of polyol pathway activity in diabetic and galactosemic rats by the aldose reductase inhibitor CP-45,634.醛糖还原酶抑制剂CP - 45,634对糖尿病和半乳糖血症大鼠多元醇途径活性的抑制作用。

Adv Exp Med Biol. 1979;119:347-56. doi: 10.1007/978-1-4615-9110-8_51.

2

CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.CP - 45,634：一种新型醛糖还原酶抑制剂，可抑制糖尿病和半乳糖血症大鼠的多元醇途径活性。

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3

The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.醛糖还原酶抑制对糖尿病和半乳糖血症大鼠神经山梨醇及肌醇浓度的影响。

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The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.一种新型醛糖还原酶抑制剂（托瑞司他）对半乳糖血症大鼠和糖尿病大鼠的影响。

Metabolism. 1985 Oct;34(10):885-92. doi: 10.1016/0026-0495(85)90133-7.

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Effect of SG-210, a novel aldose reductase inhibitor, on impaired polyol pathway in rats received diabetic manipulations.新型醛糖还原酶抑制剂SG-210对接受糖尿病处理的大鼠多元醇途径受损的影响。

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Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.新型醛糖还原酶抑制剂ICI 128,436的特性及其对大鼠糖尿病并发症的影响。

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Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.源自异喹啉-1,3-二酮的新型螺琥珀酰亚胺醛糖还原酶抑制剂：2-[(4-溴-2-氟苯基)甲基]-6-氟螺[异喹啉-4(1H),3'-吡咯烷]-1,2',3,5'(2H)-四酮及其类似物。1.

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N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.N-[5-(三氟甲基)-6-甲氧基-1-萘基]硫代甲基]-N-甲基甘氨酸（托瑞司他），一种强效的口服活性醛糖还原酶抑制剂。

J Med Chem. 1984 Mar;27(3):255-6. doi: 10.1021/jm00369a003.

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Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.半乳糖血症和糖尿病大鼠中的多元醇蓄积：醛糖还原酶抑制剂的调控作用

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Reduced anterograde and retrograde accumulation of axonally transported phosphofructokinase in streptozotocin-diabetic rats: effects of insulin and the aldose reductase inhibitor 'Statil'.链脲佐菌素诱导的糖尿病大鼠轴突运输磷酸果糖激酶的顺行和逆行积累减少：胰岛素和醛糖还原酶抑制剂“Statil”的作用

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Effects of aldose reductase inhibition on the retina and health indices of streptozotocin-diabetic rats.醛糖还原酶抑制对链脲佐菌素诱导糖尿病大鼠视网膜及健康指标的影响。

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