Yue D K, Hanwell M A, Satchell P M, Handelsman D J, Turtle J R
Metabolism. 1984 Dec;33(12):1119-22. doi: 10.1016/0026-0495(84)90097-0.
The interrelationship between sorbitol excess and myoinositol deficiency in the peripheral nerve was examined in acutely diabetic rats. Nerve myoinositol concentration was also studied in galactosemic rats. Polyol pathway blockade with Sorbinil (Pfizer, Connecticut) prevented nerve myoinositol reduction in both groups of animals. This conclusion was independent of alteration in the fluid content of the peripheral nerve. It is likely that myoinositol loss from nerves is causally related to the sorbitol and galactitol accumulation.
在急性糖尿病大鼠中研究了外周神经中山梨醇过量与肌醇缺乏之间的相互关系。还对半乳糖血症大鼠的神经肌醇浓度进行了研究。用Sorbinil（辉瑞公司，康涅狄格州）阻断多元醇途径可防止两组动物的神经肌醇减少。这一结论与外周神经液体含量的改变无关。神经中肌醇的丢失可能与山梨醇和半乳糖醇的积累有因果关系。
