半乳糖血症和糖尿病大鼠中的多元醇蓄积：醛糖还原酶抑制剂的调控作用
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
作者信息
Dvornik E, Simard-Duquesne N, Krami M, Sestanj K, Gabbay K H, Kinoshita J H, Varma S D, Merola L O
出版信息
Science. 1973 Dec 14;182(4117):1146-8. doi: 10.1126/science.182.4117.1146.
An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose. When given orally, AY-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactosemic rats with AY-22,284 effectively suppressed the formation of cataracts.
一种醛糖还原酶的口服活性抑制剂，1,3 - 二氧代 - 1H - 苯并[de] - 异喹啉 - 2(3H)乙酸（AY - 22,284），可防止暴露于高浓度半乳糖的培养晶状体发生白内障变化。口服AY - 22,284时，可显著降低半乳糖血症大鼠和链脲佐菌素诱导糖尿病大鼠晶状体和坐骨神经中多元醇的积累。此外，用AY - 22,284治疗半乳糖血症大鼠可有效抑制白内障的形成。
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