Hou A J, Zhao Q S, Li M L, Jiang B, Lin Z W, Sun H D, Zhou Y P, Lu Y, Zheng Q T
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.
Phytochemistry. 2001 Sep;58(1):179-83. doi: 10.1016/s0031-9422(01)00164-9.
Four 7,20-epoxy ent-kaurane diterpenoids, xerophilusins G (1) and I-K (2-4), were isolated from the leaves of Isodon xerophilus, along with four known ones, enanderianin C (5), rosthorin A (6), longikaurin B (7), and rabdoternin D (8). Their structures were determined primarily using NMR spectroscopic techniques. The structure and stereochemistry of 3 were confirmed by X-ray crystallography. Compounds 4 and 7 exhibited broad cytotoxicity against four kinds of human tumor cells (K562, HL-60, HCT, and MKN-28 cells) in the range of 2.23-15.35 and 0.30-8.61 microg/ml, respectively.
从耐旱香茶菜（Isodon xerophilus）叶中分离得到4个7,20-环氧对映-贝壳杉烷二萜类化合物，即耐旱香茶菜素G（1）和I-K（2-4），以及4个已知化合物，对映贝壳杉烷二萜烯C（5）、肉叶香茶菜甲素（6）、长叶香茶菜素B（7）和香茶菜萜二醇D（8）。其结构主要通过核磁共振波谱技术确定。化合物3的结构和立体化学通过X射线晶体学得以确证。化合物4和7分别在2.23-15.35和0.30-8.61微克/毫升范围内对4种人类肿瘤细胞（K562、HL-60、HCT和MKN-28细胞）表现出广泛的细胞毒性。
