Hou A J, Li M L, Jiang B, Lin Z W, Ji S Y, Zhou Y P, Sun H D
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.
J Nat Prod. 2000 May;63(5):599-601. doi: 10.1021/np9903705.
Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophilus. Their structures were elucidated on the basis of their spectral properties and X-ray crystallographic analysis. Compounds 1, 2, and 4 showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.
从耐旱香茶菜（Isodon xerophilus）的叶子中分离出三种新的7,20:14,20 - 二环氧 - 对映 - 贝壳杉烷二萜类化合物，即耐旱香茶菜素A - C（1 - 3），以及一种已知化合物大叶香茶菜素B（4）。根据它们的光谱性质和X射线晶体学分析确定了其结构。化合物1、2和4对K562、HL - 60和MKN - 28细胞显示出显著的细胞毒性活性。
