来自小叶香茶菜的7α,20-环氧对映贝壳杉烷型二萜类化合物。

7alpha,20-epoxy-ent-kauranoids from Isodon parvifolius.

作者信息

Li Li-Mei, Li Guo-You, Huang Sheng-Xiong, Li Sheng-Hong, Zhou Yan, Xiao Wei-Lie, Lou Li-Guang, Ding Li-Sheng, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2006 Apr;69(4):645-9. doi: 10.1021/np0600200.

DOI:10.1021/np0600200

PMID:16643043

Abstract

Nine new 7alpha,20-epoxy-ent-kaurane diterpenoids, parvifolines C-K (1-9), together with 12 known analogues, rabdoternin G (10), adenolin E (11), lasiodonin (12), lushanrubescensin F (13), parvifoliside (14), effusanin A (15), effusanin B (16), effusanin E (17), taibaihenryiin A (18), shikokianin (19), maoyecrystal J (20), and the acetonide of lasiodonin (21), were isolated from the leaves of Isodon parvifolius. The structures of compounds 1-9 were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. The new diterpenoids (1-9) and lasiodonin (12) were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines.

摘要

从小叶香茶菜的叶子中分离得到了9个新的7α,20-环氧-对映-贝壳杉烷二萜类化合物，即小叶香茶菜素C-K（1-9），以及12个已知类似物，即香茶菜萜宁G（10）、腺花素E（11）、毛萼晶甲（12）、庐山香茶菜素F（13）、小叶香茶菜苷（14）、疏花毛萼甲素A（15）、疏花毛萼甲素B（16）、疏花毛萼甲素E（17）、太白香茶菜素A（18）、日本香茶菜素（19）、毛叶香茶菜结晶J（20）以及毛萼晶甲的丙酮化物（21）。通过包括广泛的一维和二维核磁共振分析在内的光谱方法确定了化合物1-9的结构。对新的二萜类化合物（1-9）和毛萼晶甲（12）进行了对A549、HT-29和K562细胞系的抑制活性评估。