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合成四肽埃皮塔隆可恢复衰老猴子中紊乱的神经内分泌调节。

Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.

作者信息

Khavinson V, Goncharova N, Lapin B

机构信息

St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Prospect, 197110 St. Petersburg, Russia.

出版信息

Neuro Endocrinol Lett. 2001 Aug;22(4):251-4.

PMID:11524632
Abstract

UNLABELLED

The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys.

MATERIAL AND METHODS

We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.

RESULTS

Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion.

摘要

未标注

本研究的目的是调查埃替隆对衰老猴子褪黑素和皮质醇分泌的调节作用。

材料与方法

我们通过免疫酶测定法研究了不同年龄段接受埃替隆治疗的雌性恒河猴中褪黑素和皮质醇的分泌特征。

结果

已证实埃替隆能显著刺激衰老猴子在夜间合成褪黑素，从而使皮质醇分泌的昼夜节律正常化。

相似文献

1
Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.合成四肽埃皮塔隆可恢复衰老猴子中紊乱的神经内分泌调节。
Neuro Endocrinol Lett. 2001 Aug;22(4):251-4.
2
[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people].[松果体肽对老年猴和老年人褪黑素昼夜节律的正常化作用]
Adv Gerontol. 2007;20(1):74-85.
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Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.松果体肽可恢复松果体和胰腺激素功能中与年龄相关的紊乱。
Exp Gerontol. 2005 Jan-Feb;40(1-2):51-7. doi: 10.1016/j.exger.2004.10.004.
4
Peptides and Ageing.肽与衰老
Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.
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[Peptide correction of age-related pineal disturbances in monkeys].[肽对猴子年龄相关的松果体紊乱的纠正作用]
Adv Gerontol. 2003;12:121-7.
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Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.埃匹他隆对老年猴子褪黑素和皮质醇分泌的调节作用。
Bull Exp Biol Med. 2001 Apr;131(4):394-6. doi: 10.1023/a:1017928925177.
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Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta.内在生物钟和睡眠在昼行性非人灵长类动物猕猴中的衰老。
J Biol Rhythms. 2011 Apr;26(2):149-59. doi: 10.1177/0748730410395849.
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[Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging].
Eksp Klin Farmakol. 2006 Nov-Dec;69(6):13-6.
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[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].[依普他隆和褪黑素对衰老加速小鼠（SAM）寿命及自发致癌作用的影响]
Vopr Onkol. 2005;51(1):93-8.
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Intrinsic activity rhythms in Macaca mulatta: their entrainment to light and melatonin.恒河猴内在活动节律：对光和褪黑素的适应。
J Biol Rhythms. 2010 Oct;25(5):361-71. doi: 10.1177/0748730410379382.

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Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.埃皮塔隆概述——具有潜在特性的高生物活性松果体四肽
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Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease.超短肽在阿尔茨海默病中的神经表观遗传作用机制。
Int J Mol Sci. 2022 Apr 12;23(8):4259. doi: 10.3390/ijms23084259.
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Effect of short peptides on neuronal differentiation of stem cells.短肽对干细胞神经元分化的影响。
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Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation.下丘脑-垂体-肾上腺轴的应激反应：神经加压素调节的与年龄相关的特征。
Front Endocrinol (Lausanne). 2013 Mar 12;4:26. doi: 10.3389/fendo.2013.00026. eCollection 2013.
7
Aging of the hypothalamic-pituitary-adrenal axis in nonhuman primates with depression-like and aggressive behavior.具有抑郁样和攻击性行为的非人灵长类动物下丘脑-垂体-肾上腺轴的老化
Aging (Albany NY). 2010 Nov;2(11):854-66. doi: 10.18632/aging.100227.
8
Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.一种合成松果体四肽（丙氨酸-谷氨酸-天冬氨酸-甘氨酸）对幼年和老年大鼠松果体褪黑素分泌的影响。
J Endocrinol Invest. 2003 Mar;26(3):211-5. doi: 10.1007/BF03345159.