Levy S B
Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA.
Clin Infect Dis. 2001 Sep 15;33 Suppl 3:S124-9. doi: 10.1086/321837.
Bacterial resistance presents therapeutic dilemmas to clinicians worldwide. The warnings were there long ago, but too few people heeded them. Thus an emerging problem has grown to a crisis. Resistance is an ecological phenomenon stemming from the response of bacteria to the widespread use of antibiotics and their presence in the environment. While determining the consequences of inaction on the present and future public health, we must work to remedy the lack of action in the past. By improving antibiotic use and decreasing resistance gene frequency at the local levels, we can move towards reversing the resistance problem globally.
细菌耐药性给全球临床医生带来了治疗难题。这些警告早就存在，但很少有人留意。因此，一个新出现的问题已演变成一场危机。耐药性是一种生态现象，源于细菌对广泛使用抗生素及其在环境中存在的反应。在确定不作为对当前和未来公共卫生的影响时，我们必须努力弥补过去行动的不足。通过在地方层面改善抗生素使用并降低耐药基因频率，我们能够朝着在全球范围内扭转耐药性问题的方向迈进。
