抗组胺药及相关药物对二胺氧化酶的抑制作用。
Inhibition of diamine oxidase by antihistaminic agents and related drugs.
作者信息
Finazzi-Agrò A, Floris G, Fadda M B, Crifò C
出版信息
Agents Actions. 1979 Aug;9(3):244-7. doi: 10.1007/BF01966695.
PMID:115254
Abstract
Various drugs were tested as inhibitors of diamine oxidase on the basis of chemical relationships to the enzyme substrates. It was found that serotonine tryptamine and phenformin are good competitive inhibitors while cimetidine and pheniprazine are non-competitive inhibitors. Other antihistaminic drugs like promethazine are less powerful inhibitors.
摘要
基于与酶底物的化学关系，对多种药物作为二胺氧化酶抑制剂进行了测试。发现血清素、色胺和苯乙双胍是良好的竞争性抑制剂，而西咪替丁和苯异丙肼是非竞争性抑制剂。其他抗组胺药物如异丙嗪是效力较弱的抑制剂。
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