Lu Q R, Park J K, Noll E, Chan J A, Alberta J, Yuk D, Alzamora M G, Louis D N, Stiles C D, Rowitch D H, Black P M
Department of Cancer Biology, the Program in Neuro-oncology, Dana-Farber/Harvard Cancer Center, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10851-6. doi: 10.1073/pnas.181340798. Epub 2001 Aug 28.
The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig1/2) encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.
人们认为人类脑内最常见的原发性肿瘤起源于神经胶质细胞。然而，神经胶质细胞瘤无法通过细胞形态学或使用星形胶质细胞、少突胶质细胞或其祖细胞的传统标志物进行完全分类。近期对中枢神经系统肿瘤发生的深入了解表明，在参与神经胶质发育的因子中可能会发现新的分子标志物。少突胶质细胞谱系基因（Olig1/2）编码碱性螺旋-环-螺旋转录因子。在啮齿动物的中枢神经系统中，它们仅在少突胶质细胞和少突胶质细胞祖细胞中表达，并且Olig1可以促进硫酸软骨素蛋白聚糖阳性神经胶质祖细胞的形成。在此我们表明，人类OLIG基因在少突胶质细胞瘤中强烈表达，而在星形细胞瘤中则无表达或低表达。我们的数据提供了证据，证明少突胶质细胞瘤的肿瘤细胞类似于少突胶质细胞或其祖细胞，并且可能源自该谱系的细胞。它们进一步提示了OLIG标志物在增强少突胶质细胞瘤识别方面的诊断潜力。
