Blanchette N, Smith M L, Fernandes-Penney A, King S, Read S
Brain Cogn. 2001 Jun-Jul;46(1-2):50-3. doi: 10.1016/s0278-2626(01)80032-4.
This study was designed to examine mental and motor development in infants with vertically transmitted human immunodeficiency virus (HIV) infection. Early neurodevelopment was examined in 25 young children with HIV infection acquired through vertical transmission. Compared with 25 children born to HIV-positive mothers but not infected with the virus, and after controlling for developmental risk factors, the HIV-infected group showed impairments in mental and motor development. Mental and motor development were assessed using the Bayley Scales of Infant Development. On the mental scale (MDI), the HIV-infected infants obtained significantly lower scores than the uninfected infants. On the performace scale (PDI), the HIV-infected infants obtained significantly lower standard scores than the uninfected infants. CT scan results were available for 20 of the HIV-infected children. CT abnormalities were associated with developmental delays, particularly for motor development. The results point to the importance of early abnormalities in myelination and of subcortical lesions of cognitive and motor development.
本研究旨在检测垂直传播的人类免疫缺陷病毒（HIV）感染婴儿的智力和运动发育情况。对25例经垂直传播感染HIV的幼儿进行了早期神经发育检查。将其与25例母亲为HIV阳性但未感染该病毒的儿童进行比较，并在控制发育危险因素后，发现HIV感染组在智力和运动发育方面存在损害。使用贝利婴儿发育量表对智力和运动发育进行评估。在智力量表（MDI）上，HIV感染婴儿的得分显著低于未感染婴儿。在行为量表（PDI）上，HIV感染婴儿的标准得分显著低于未感染婴儿。20例HIV感染儿童有CT扫描结果。CT异常与发育迟缓有关，尤其是运动发育迟缓。结果表明早期髓鞘形成异常以及认知和运动发育的皮质下病变具有重要意义。
