Steinemann S, Steinemann M
Institut für Zoologie, Technische Universität Darmstadt, Darmstadt, Germany.
Cytogenet Cell Genet. 2001;93(3-4):228-33. doi: 10.1159/000056988.
It is generally assumed that the sex chromosomes developed from a pair of homologs. Over evolution, the proto-Y chromosome, with a very short differential segment, matured in its final stage into a heterochromatic and, for the most part, genetically eroded Y chromosome. The constraints on the evolution of the proto-Y chromosome have been speculated upon since the sex chromosomes were discovered. Several models have been suggested. Drosophila miranda has proved to be a unique and potent model system to study Y-chromosome evolution. We use selected test genes distributed along the neo-Y chromosome as entry gates to analyze the molecular mechanisms involved in the process of Y-chromosome evolution. Here, we report our findings on the Krüppel gene (Kr), which is located distally on the neo-sex chromosome pair.
一般认为，性染色体由一对同源染色体进化而来。在进化过程中，原始Y染色体具有非常短的差异区段，在其最后阶段成熟为异染色质且在很大程度上基因受到侵蚀的Y染色体。自从发现性染色体以来，人们一直在推测原始Y染色体进化的限制因素。已经提出了几种模型。事实证明，米兰达果蝇是研究Y染色体进化的独特而有效的模型系统。我们使用沿着新Y染色体分布的选定测试基因作为切入点，来分析Y染色体进化过程中涉及的分子机制。在此，我们报告我们对位于新性染色体对远端的Krüppel基因（Kr）的研究结果。
