Eekhof J L, Aramideh M, Speelman J D, Ongerboer de Visser B W
Department of Neurology, Academic Medical Centre, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands.
Eur Neurol. 2001;46(2):75-8. doi: 10.1159/000050767.
To investigate possible abnormalities of the blink reflex pathways, we analyzed the latencies and amplitudes of the blink reflex responses in the orbicularis oculi (Ooculi) muscle, following supraorbital nerve stimulation, in 19 patients with blepharospasm, 16 patients with torticollis spasmodica and 22 control subjects. Furthermore, in order to examine the suprasegmental control of the responses, the reflex responses were also evoked in the orbicularis oris (Ooris) muscle after stimulation of the ipsilateral supraorbital nerve. The responses were recorded only when subjects had no contractions of the eyelid muscles, either involuntarily, voluntarily or spontaneously; this could be controlled by a sound signal. The metrics of the reflex responses in the Ooculi and Ooris muscles in patient groups were comparable to those in controls. Our data indicate that the afferent and efferent pathways of the reflex arc and the suprasegmental control of the reflex are intact in patients with blepharospasm and torticollis spasmodica, at least during spasm-free intervals. Alterations of responses may occur during spasms due to either segmental or suprasegmental changes.
为了研究瞬目反射通路可能存在的异常，我们分析了19例睑痉挛患者、16例痉挛性斜颈患者和22例对照者在眶上神经刺激后眼轮匝肌（Ooculi）的瞬目反射反应的潜伏期和波幅。此外，为了检查反应的节段上控制，在刺激同侧眶上神经后，也在口轮匝肌（Ooris）诱发反射反应。仅当受试者的眼睑肌肉无不由自主、自主或自发收缩时才记录反应；这可通过声音信号进行控制。患者组眼轮匝肌和口轮匝肌的反射反应指标与对照组相当。我们的数据表明，至少在无痉挛间期，睑痉挛和痉挛性斜颈患者的反射弧传入和传出通路以及反射的节段上控制是完整的。由于节段性或节段上的变化，痉挛期间可能会出现反应改变。
