Eekhof J L, Aramideh M, Bour L J, Hilgevoord A A, Speelman H D, Ongerboer de Visser B W
Graduate School Neurosciences Amsterdam, AZUA, Department of Neurology, The Netherlands.
Muscle Nerve. 1996 Jan;19(1):10-5. doi: 10.1002/(SICI)1097-4598(199601)19:1<10::AID-MUS2>3.0.CO;2-B.
R1 and R2 blink reflex responses to single and paired stimuli were investigated in 23 control subjects, 21 patients with blepharospasm (BSP), 20 patients with torticollis spasmodica (TS), and 23 with hemifacial spasm (HFS). For paired stimuli, we compared measurements of area and peak responses at two and three times R2 threshold. R1 and R2 indices were calculated as the average of the recovery values at 0.5-, 0.3-, and 0.21-s interstimulus intervals to test individual patients. Peak amplitude measurements at three times R2 threshold were optimal. The R2 index was abnormal in 67% of BSP patients, 37% of TS patients, and 50% of HFS patients on the affected side and 20% on the unaffected side. A normal R2 index in one third of patients with BSP may indicate that different pathophysiological mechanisms are involved in this type of focal dystonia.
在23名对照受试者、21名眼睑痉挛（BSP）患者、20名痉挛性斜颈（TS）患者和23名面肌痉挛（HFS）患者中，研究了R1和R2对单次和配对刺激的眨眼反射反应。对于配对刺激，我们比较了在R2阈值的两倍和三倍时的面积和峰值反应测量值。计算R1和R2指数作为在0.5秒、0.3秒和0.21秒刺激间隔时恢复值的平均值，以测试个体患者。在R2阈值的三倍时进行的峰值幅度测量是最佳的。在受影响侧，67%的BSP患者、37%的TS患者和50%的HFS患者的R2指数异常，在未受影响侧，20%的患者R2指数异常。三分之一的BSP患者R2指数正常，这可能表明这种类型的局灶性肌张力障碍涉及不同的病理生理机制。
