Le Van Quyen M, Martinerie J, Navarro V, Baulac And M, Varela F J
LENA (laboratoire de Neurosciences Cognitives et Imagerie Cérébrale), CNRS UPR 640, Paris, France.
J Clin Neurophysiol. 2001 May;18(3):191-208. doi: 10.1097/00004691-200105000-00001.
The study of dynamic changes in neural activity preceding epileptic seizure allows the characterization of a preictal state several minutes before seizure onset. This opens up new perspectives for studying the mechanisms of epileptogenesis as well as for possible therapeutic interventions, which represent a major breakthrough. In this review the authors present and discuss the results from their group in this domain using nonlinear analysis of brain signals, as well as the limitations of this topic and current questions.
对癫痫发作前神经活动动态变化的研究能够在发作开始前几分钟对发作前期状态进行特征描述。这为研究癫痫发生机制以及可能的治疗干预开辟了新的视角，这是一项重大突破。在这篇综述中，作者展示并讨论了他们团队在该领域使用脑信号非线性分析得出的结果，以及该主题的局限性和当前存在的问题。
