Wartanowicz M, Ziemlański S, Bułhak-Jachymczyk B, Konopka L
Department of Physiology and Biochemistry of Nutrition, Institute of Food and Nutrition, Warsaw, Poland.
Eur J Clin Nutr. 2001 Sep;55(9):743-7. doi: 10.1038/sj.ejcn.1601217.
The aim of the study was to investigate folate and other selected vitamin status (ascorbic acid, tocopherol, retinol, vitamin B12), haematological indices and total homocysteine concentration of serum in women of childbearing age.
A cross-sectional study.
Warsaw.
Healthy women aged 18-30 y (n=78) not pregnant presently or previously, and not taking drugs.
Haemoglobin and haematocrit values according to WHO criteria for 18 to 30-y-old women were normal. The optimal levels of serum tocopherol, >1.29 mg/dl (>29.9 micromol/l) to preventing civilization diseases, were found in 5.5% and serum retinol >71.6 mcg/dl (>2.5 micromol/l) in 6.4% of all studied persons. The analysis of serum folate concentration showed high-risk deficiency,<3 ng/ml (<6.8 nmol/l), in 6.4%, moderate and low risk together (7.0-14.9 nmol/l) in 61.6% and optimal folate levels (>14.9 nmol/l) in 32.0% of the studied group. Folate body stores were insufficient in almost all women. There was no high or moderate deficiency risk of vitamin B12 or ascorbic acid. None of the women under study had serum total homocysteine (tHcy) concentration >15 micromol/l, indicating hyperhomocysteinaemia. Serum total homocysteine concentrations in the range of 5-15 micromol/l were found in 71.8%, and serum tHcy >10 micromol/l in 7.7% of the studied group of women.
The study was sponsored by the Polish Committee for Scientific Research.
本研究旨在调查育龄妇女血清中的叶酸及其他选定维生素（抗坏血酸、生育酚、视黄醇、维生素B12）状态、血液学指标及总同型半胱氨酸浓度。
横断面研究。
华沙。
18至30岁的健康女性（n = 78），目前及既往均未怀孕，且未服用药物。
根据世界卫生组织标准，18至30岁女性的血红蛋白和血细胞比容值正常。在所有研究对象中，5.5%的人血清生育酚水平>1.29 mg/dl（>29.9 μmol/l），这一水平对预防慢性病最为理想；6.4%的人血清视黄醇>71.6 μg/dl（>2.5 μmol/l）。血清叶酸浓度分析显示，6.4%的研究对象存在高危缺乏（<3 ng/ml，<6.8 nmol/l），61.6%的人处于中低风险（7.0 - 14.9 nmol/l），32.0%的人叶酸水平最佳（>14.9 nmol/l）。几乎所有女性的叶酸体内储备均不足。维生素B12或抗坏血酸不存在高或中度缺乏风险。所有研究对象的血清总同型半胱氨酸（tHcy）浓度均未>15 μmol/l，即不存在高同型半胱氨酸血症。71.8%的研究对象血清总同型半胱氨酸浓度在5 - 15 μmol/l范围内，7.7%的人血清tHcy>10 μmol/l。
本研究由波兰科学研究委员会资助。
