Fayet-Moore Flavia, Petocz Peter, Samman Samir
Discipline of Nutrition & Metabolism, School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
Department of Statistics, Macquarie University, Ryde, NSW 2112, Australia.
Nutrients. 2014 Nov 13;6(11):5103-16. doi: 10.3390/nu6115103.
Young women are at an increased risk of micronutrient deficiencies, particularly due to higher micronutrient requirements during childbearing years and multiple food group avoidances. The objective of this study was to investigate biomarkers of particular micronutrients in apparently healthy young women. Female students (n = 308; age range 18-35 year; Body Mass Index 21.5 ± 2.8 kg/m2; mean ± SD) were recruited to participate in a cross-sectional study. Blood samples were obtained from participants in the fasted state and analysed for biomarkers of iron status, vitamin B12, folate, homocysteine, selenium, zinc, and copper. The results show iron deficiency anaemia, unspecified anaemia, and hypoferritinemia in 3%, 7% and 33.9% of participants, respectively. Low vitamin B12 concentrations (<120 pmol/L) were found in 11.3% of participants, while 4.7% showed sub-clinical deficiency based on serum methylmalonic acid concentrations >0.34 μmol/L. Folate concentrations below the reference range were observed in 1.7% (serum) or 1% (erythrocytes) of participants, and 99.7% of the participant had erythrocyte-folate concentrations >300 nmol/L. Serum zinc concentrations <10.7 μmol/L were observed in 2% of participants. Serum copper and selenium concentrations were below the reference range in 23% and 11% of participants, respectively. Micronutrient deficiencies including iron and vitamin B12, and apparent excess of folate are present in educated Australian female students of childbearing age, including those studying nutrition. The effects of dietary behaviours and food choices on markers of micronutrient status require further investigation.
年轻女性患微量营养素缺乏症的风险更高,尤其是由于育龄期对微量营养素的需求增加以及多种食物组的忌口。本研究的目的是调查明显健康的年轻女性体内特定微量营养素的生物标志物。招募了女学生(n = 308;年龄范围18 - 35岁;体重指数21.5 ± 2.8 kg/m²;均值 ± 标准差)参与一项横断面研究。在空腹状态下采集参与者的血样,并分析铁状态、维生素B12、叶酸、同型半胱氨酸、硒、锌和铜的生物标志物。结果显示,分别有3%、7%和33.9%的参与者患有缺铁性贫血、未明确的贫血和低铁蛋白血症。11.3%的参与者维生素B12浓度较低(<120 pmol/L),而基于血清甲基丙二酸浓度>0.34 μmol/L,4.7%的参与者表现为亚临床缺乏。1.7%(血清)或1%(红细胞)的参与者叶酸浓度低于参考范围,99.7%的参与者红细胞叶酸浓度>300 nmol/L。2%的参与者血清锌浓度<10.7 μmol/L。分别有23%和11%的参与者血清铜和硒浓度低于参考范围。包括铁和维生素B12在内的微量营养素缺乏以及明显的叶酸过量存在于澳大利亚育龄期受过教育的女学生中,包括那些学习营养学的学生。饮食行为和食物选择对微量营养素状态标志物的影响需要进一步研究。