Aroutcheva A A, Simoes J A, Behbakht K, Faro S
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA.
Clin Infect Dis. 2001 Oct 1;33(7):1022-7. doi: 10.1086/323030. Epub 2001 Sep 5.
The differences in the phenotype and genotype of Gardnerella vaginalis isolates from patients with bacterial vaginosis (BV) and from patients without BV are unknown. In our study, 43 isolates of G. vaginalis were examined for biotype (hippurate hydrolysis, lipase, and beta-galactosidase activity), sensitivity to metronidazole, and genotype. Of the 117 women visiting the gynecology clinic at Rush-Presbyterian-St. Luke's Medical Center who were included in the study, 27.4% were found to have BV. G. vaginalis was found in samples from 87.5% of women with BV, from 34.0% of women with intermediate BV, and from 26.4% of women with healthy vaginal ecosystems. Among patients with G. vaginalis, biotypes 7 and 8 were isolated from 32% and 20% of patients, respectively. Biotype 5 was predominantly associated with a healthy vaginal ecosystem (P=.0004). Biotypes 5 and 7 were the most resistant to metronidazole. No specific phenotype or genotype of G. vaginalis causes BV.
来自细菌性阴道病（BV）患者和非BV患者的阴道加德纳菌分离株在表型和基因型上的差异尚不清楚。在我们的研究中，对43株阴道加德纳菌进行了生物型（马尿酸盐水解、脂肪酶和β-半乳糖苷酶活性）、对甲硝唑的敏感性及基因型检测。在拉什长老会圣卢克医疗中心妇科门诊就诊并纳入研究的117名女性中，发现27.4%患有BV。在87.5%的BV女性、34.0%的中度BV女性和26.4%阴道生态系统健康的女性样本中发现了阴道加德纳菌。在阴道加德纳菌患者中，分别从32%和20%的患者中分离出生物型7和8。生物型5主要与健康的阴道生态系统相关（P = 0.0004）。生物型5和7对甲硝唑最耐药。没有特定的阴道加德纳菌表型或基因型会导致BV。
