Lipowsky R, Klumpp S, Nieuwenhuizen T M
Max-Planck-Institut für Kolloid und Grenzflächenforschung, 14424 Potsdam, Germany.
Phys Rev Lett. 2001 Sep 3;87(10):108101. doi: 10.1103/PhysRevLett.87.108101. Epub 2001 Aug 17.
Random walks of molecular motors, which bind to and unbind from cytoskeletal filaments, are studied theoretically. The bound and unbound motors undergo directed and nondirected motion, respectively. Motors in open compartments exhibit anomalous drift velocities. Motors in closed compartments generate stationary nonequilibrium states with spatially varying densities of the motor concentrations and currents. "Traffic jams" on the filaments lead to a maximum of the motor current at an optimal motor concentration. Quantitative estimates based on experimental data for bound motors indicate that these transport phenomena are accessible to experiments.
对与细胞骨架丝结合和解离的分子马达的随机游走进行了理论研究。结合态和游离态的马达分别经历定向运动和非定向运动。开放隔室内的马达表现出异常漂移速度。封闭隔室内的马达产生具有马达浓度和电流空间变化密度的稳态非平衡态。丝上的“交通堵塞”导致在最佳马达浓度下马达电流达到最大值。基于结合态马达实验数据的定量估计表明，这些传输现象是实验可及的。
