基因筛选的技术与设计：酵母

The art and design of genetic screens: yeast.

作者信息

Forsburg S L

机构信息

Molecular and Cell Biology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

Nat Rev Genet. 2001 Sep;2(9):659-68. doi: 10.1038/35088500.

DOI:10.1038/35088500

PMID:11533715

Abstract

Understanding the biology of complex systems is facilitated by comparing them with simpler organisms. Budding and fission yeasts provide ideal model systems for eukaryotic cell biology. Although they differ from one another in terms of a range of features, these yeasts share powerful genetic and genomic tools. Classical yeast genetics remains an essential element in discovering and characterizing the genes that make up a eukaryotic cell.

摘要

将复杂系统与更简单的生物体进行比较，有助于理解其生物学特性。出芽酵母和裂殖酵母为真核细胞生物学提供了理想的模型系统。尽管它们在一系列特征方面存在差异，但这些酵母共享强大的遗传和基因组工具。经典的酵母遗传学仍然是发现和表征构成真核细胞的基因的重要元素。