芽殖酵母与人类动粒之间的进化保守性。
Evolutionary conservation between budding yeast and human kinetochores.
作者信息
Kitagawa K, Hieter P
机构信息
Department of Molecular Pharmacology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105-2794, USA.
出版信息
Nat Rev Mol Cell Biol. 2001 Sep;2(9):678-87. doi: 10.1038/35089568.
DOI:10.1038/35089568
PMID:11533725
Abstract
Accurate chromosome segregation during mitosis requires the correct assembly of kinetochores--complexes of centromeric DNA and proteins that link chromosomes to spindle microtubules. Studies on the kinetochore of the budding yeast Saccharomyces cerevisiae have revealed functionally novel components of the kinetochore and its regulatory complexes, some of which are highly conserved in humans.
摘要
有丝分裂期间准确的染色体分离需要动粒的正确组装，动粒是着丝粒DNA和将染色体与纺锤体微管相连的蛋白质的复合体。对芽殖酵母酿酒酵母动粒的研究揭示了动粒及其调控复合体中功能上新的组分，其中一些在人类中高度保守。
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