[发热与实体肿瘤：降钙素原和C反应蛋白的诊断价值]
[Fever and solid tumor: diagnostic value of procalcitonin and C-reactive protein].
作者信息
Penel N, Fournier C, Degardin M, Kouto H, N'Guyen M
机构信息
Département de cancérologie cervicofaciale, centre Oscar-Lambret, 3, rue F.-Combemale, 59020 Lille, France.
出版信息
Rev Med Interne. 2001 Aug;22(8):706-14. doi: 10.1016/s0248-8663(01)00416-7.
PURPOSE
Evaluate the clinical utility of procalcitonin (PCT) and C-reactive protein (CRP) as diagnostic of paraneoplastic fever.
METHOD
A prospective analysis of serum levels of PCT and CRP has been conducted on 68 consecutive febrile patients with solid tumour and no neutropenia. The samples were collected at hospital admission.
RESULTS
Out of 68 patients, 57 had head and neck cancer. Forty-three patients had signs of infection and 19 had paraneoplastic fever. CRP was not significantly different between the two groups (infected patients: median: 134 mg/L, extremes: 20-569; paraneoplastic fever patients: median: 154 mg/L, extremes: 26-267; P = 0.75 with Mann-Whitney test). On the other hand, PCT was significantly higher in case of infection (median: 0.44 ng/mL, extremes: 0.09-57.4) than in the case of paraneoplastic fever (median: 0.26 ng/mL, extremes: 0.05-1.17; P = 0.01 with Mann-Whitney test).
CONCLUSION
In our study, no paraneoplastic fever patient had PCT level equal or above 2 ng/mL (negative predictive value of 100%).
目的
评估降钙素原（PCT）和C反应蛋白（CRP）在诊断副肿瘤性发热中的临床效用。
方法
对68例连续的患有实体肿瘤且无中性粒细胞减少症的发热患者进行了PCT和CRP血清水平的前瞻性分析。样本在入院时采集。
结果
68例患者中，57例患有头颈癌。43例患者有感染迹象，19例有副肿瘤性发热。两组之间CRP无显著差异（感染患者：中位数：134mg/L，范围：20 - 569；副肿瘤性发热患者：中位数：154mg/L，范围：26 - 267；曼-惠特尼检验P = 0.75）。另一方面，感染时PCT显著高于副肿瘤性发热（中位数：0.44ng/mL，范围：0.09 - 57.4）（中位数：0.26ng/mL，范围：0.05 - 1.17；曼-惠特尼检验P = 0.01）。
结论
在我们的研究中，没有副肿瘤性发热患者的PCT水平等于或高于2ng/mL（阴性预测值为100%）。
Zotero 插件