Vargay Z, Simon G, Winter M, Szüts T
Eur J Drug Metab Pharmacokinet. 1980;5(2):69-74. doi: 10.1007/BF03189448.
After oral and intravenous administration of drotaverin-14C its metabolites were determined in rat bile. Three major metabolites were identified by tlc. All the metabolites appeared in conjugated form. No unchanged drotaverine was detectable in the bile, except after treatment with doses much in excess of the therapeutic range. The ratio of major metabolites to unchanged product was determined by two-dimensional densitometry using a Telechrom Video Densitometer.
口服和静脉注射14C标记的屈他维林后，在大鼠胆汁中测定其代谢产物。通过薄层层析法鉴定出三种主要代谢产物。所有代谢产物均以结合形式出现。除用大大超过治疗范围的剂量处理后，在胆汁中未检测到未变化的屈他维林。使用Telechrom视频光密度计通过二维光密度测定法确定主要代谢产物与未变化产物的比例。
