Simon G, Vargay Z, Winter M, Szüts T
Eur J Drug Metab Pharmacokinet. 1979;4(4):213-7. doi: 10.1007/BF03189429.
The absorption and biliary excretion of drotaverin/a papaverine analogue/were studied in rats. In vivo loop technique was used. The absorption of the compounds from the jejunum was found to be rapid and the activity injected into the duodenal sac to disappear only when the common bile duct was ligated. An appreciable activity was detected in the bile collected by cannulation following both i.v. (67%) or per os (31%) administration. Considerable activity was excreted with the bile even 24 hours after drug administration. A partial entero-hepatic cycle for the drotaverin metabolites is suggested.
在大鼠中研究了屈他维林（一种罂粟碱类似物）的吸收和胆汁排泄情况。采用了体内肠袢技术。发现这些化合物从空肠的吸收迅速，并且注入十二指肠肠袢的活性仅在胆总管结扎时才消失。静脉注射（67%）或口服（31%）给药后，通过插管收集的胆汁中检测到相当量的活性。即使在给药24小时后，仍有相当量的活性随胆汁排出。提示屈他维林代谢产物存在部分肠肝循环。
