Bernaschi M, Castiglione F
Istituto Applicazioni Calcolo, CNR, V.le Policlinico 137, 00161 Roma, Italy.
Comput Biol Med. 2001 Sep;31(5):303-31. doi: 10.1016/s0010-4825(01)00011-7.
Cellular automata based models have proven capable of providing several new insights into the dynamics of the immune system (IS) response.A qualitative picture of the IS behavior can be obtained with small-scale simulations. However, for a more detailed analysis and to further validate the models, large-scale simulations are required. To this purpose we present here a simulator (PARIMM) of the IS response which has been carefully designed and coded to allow such simulations (millions of cells with a very high degree of complexity). The code does not just resort to parallel processing to run faster. Data structures and I/O have been optimized as well to limit the (huge) memory and disk space requirements. The recent addition of the description of the T killer cellular mediated response allows the code to simulate both humoral and cellular immune reactions. All these features put PARIMM among the most complete simulators of the immune system developed up today.
基于细胞自动机的模型已被证明能够为免疫系统（IS）反应的动力学提供一些新的见解。通过小规模模拟可以获得IS行为的定性描述。然而，为了进行更详细的分析并进一步验证模型，需要进行大规模模拟。为此，我们在此展示一个IS反应模拟器（PARIMM），它经过精心设计和编码，以允许进行此类模拟（数百万具有非常高复杂度的细胞）。该代码不仅仅依靠并行处理来加快运行速度。数据结构和输入/输出也经过了优化，以限制（巨大的）内存和磁盘空间需求。最近增加的T杀伤细胞介导反应的描述使该代码能够模拟体液免疫和细胞免疫反应。所有这些特性使PARIMM成为当今开发的最完整的免疫系统模拟器之一。
