Seiden P E, Celada F
IBM T. J. Watson Research Center, Yorktown Heights, NY 10598.
J Theor Biol. 1992 Oct 7;158(3):329-57. doi: 10.1016/s0022-5193(05)80737-4.
We have constructed a model of the immune system that focuses on the clonotypic cell types and their interactions with other cells, and with antigens and antibodies. We carry out simulations of the humoral immune system based on a generalized cellular automaton implementation of the model. We propose using computer simulation as a tool for doing experiments in machine, in the computer, as an adjunct to the usual in vivo and in vitro techniques. These experiments would not be intended to replace the usual biological experiments since, in the foreseeable future, a complete enough computer model capable of reliably simulating the whole immune would not be possible. However a model simulating areas of interest could be used for extensively testing ideas to help in the design of the critical biological experiments. Our present model concentrates on the cellular interactions and is quite adept at testing the importance and effects of cellular interactions with other cells, antigens and antibodies. The implementation is quite general and unrestricted allowing most other immune system components to be added with relative ease when desired.
我们构建了一个免疫系统模型，该模型专注于克隆型细胞类型及其与其他细胞、抗原和抗体的相互作用。我们基于该模型的广义细胞自动机实现对体液免疫系统进行模拟。我们提议将计算机模拟用作在机器中、在计算机内进行实验的工具，作为常规体内和体外技术的辅助手段。这些实验并非旨在取代常规生物学实验，因为在可预见的未来，构建一个足够完整且能够可靠模拟整个免疫系统的计算机模型是不可能的。然而，一个模拟感兴趣领域的模型可用于广泛测试各种想法，以帮助设计关键的生物学实验。我们目前的模型专注于细胞间相互作用，并且非常擅长测试细胞与其他细胞、抗原和抗体相互作用的重要性和影响。该实现相当通用且不受限制，允许在需要时相对轻松地添加大多数其他免疫系统组件。
